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When a young man witnesses a brutal mob murder, it falls to FBI agent Neville Flynn to escort his charge safely from Hawaii to Los Angeles to testify. But in an act of self-preservation, the crime boss facing prison smuggles hundreds of poisonous snakes onto the commercial aircraft in a crate timed to release its deadly cargo halfway over the Pacific. Flynn, along with a frightened flight crew and passengers, must then band together in a desperate attempt to survive.

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