This dark-haired attractive actor began her career in juvenile parts and made the transition to more adult roles. The daughter of 1960s folk singer Donovan, Skye was raised by her mother in California and Connecticut. She began as a child model. Director Tim Hunter saw her in a fashion layout and cast her as Clarissa in "River's Edge" (1986). Skye went on to appear as a female friend of River Phoenix's title character in "A Night in the Life of Jimmy Reardon" (1988) and gave a winning performance as high school heartthrob Diane Court in Cameron Crowe's fine, bittersweet love story, "Say Anything" (1989). She shone as the surly older daughter in Allison Anders' "Gas Food Lodging" (1992), which also co-starred her brother, actor-producer Donovan Leitch. Skye appeared as a coven member in Anders' "Strange Brew" segment of "Four Rooms" (1995) and made her directorial debut with the short comedy "Bed, Bath and Beyond" (1996), co-directed with Andrew Durham and Sofia Coppola. Skye portrayed an aspiring actress in the romantic comedy "Dream for an Insomniac" (filmed in 1996; released in 1998).
In 1992, Skye married musician-actor Adam Horovitz, the son of playwright-director Israel Horovitz. The pair appeared together in small roles in "CITYSCRAPES los angeles" (lensed in 1994; shown at festivals in 1996) but have since divorced. Meanwhile, Skye made appearances on the small screen. She made her television debut as the Emperor's younger sister in the miniseries "Napoleon and Josephine: A Love Story" (ABC, 1987), was a regular on the short-lived medieval adventure "Covington Cross" (ABC, 1992) and co-starred in the 1994 Showtime remake of the 50s drama "Girls in Prison.” After portraying a newlywed forced to deal with a possessive and controlling mother-in-law in the TV movie “The Perfect Mother” (CBS, 1997), Skye went back to film, playing the ex-girlfriend of a young man (Rick Stear) whose financial problems and descent into alcoholism ended their relationship in the independently released “Went to Coney Island on a Mission from God…Be Back by Five” (1998).
Skye made a small appearance in the little-seen and critically panned “But I’m a Cheerleader” (2000), a teen black comedy about a seemingly perfect high school student (Natasha Lyonne) who is sent to a rehabilitation camp because her parents think she’s a lesbian. She then starred in an episode of the revamped “Twilight Zone” (UPN, 2002-2003) as a woman whose brush with death from a speeding car unravels her once happy life. After playing Blythe Danner’s daughter in the made-for-TV movie “Back When We Were Grownups” (CBS, 2004), Skye went to bat in “Fever Pitch” (2005) as the friend of a corporate executive (Drew Barrymore) whose developing relationship with a rabid Boston Red Sox fan (Jimmy Fallon) begins to deteriorate when the season begins.