Photo by Screen GemsAfter delivering her fair share of thrills and chills as a zombie killer in Resident Evil: Extinction and as superhuman with a split personality on TV's Heroes, Ali Larter returns to the big screen on April 24 as a suicidal seductress in the guaranteed guilty pleasure, Obsessed. With the highly anticipated return of the female-fronted thriller, its time to revisit the femme fatales, disturbed dames, and brutal babes that have paved the way for the next generation of lethal ladies.

Photo by 20th Century Fox, Everett CollectionSigourney Weaver - Aliens
After surviving the first installment of this iconic sci-fi film franchise, Sigourney Weaver's Ripley takes the lead and faces her fears by returning to LV-426 to duke it out with facehuggers, chestbursters, and the one-and-only Alien queen before returning to hypersleep and two additional sequels.

Photo by Columbia, Everett CollectionKathy Bates - Misery
Fueled by her obsession with Paul Sheldon's work, self-proclaimed no. 1 fan Annie Wilkes wreaks havoc on the incapacitated author and demands a rewrite when she disagrees with the creative direction of his new novel. Unfortunately, Paul doesn't realize that his caretaker, a former nurse, is skilled with both sponge baths and sledgehammers.

Everett CollectionMargaret Hamilton -The Wizard of Oz
With flying monkeys for henchmen and perhaps the most recognizable quote in film history ("I'll get you, my pretty, and your little dog, too!"), Margaret Hamilton's Wicked Witch of the West continues to terrify tots as one of the big screen's most brutal broads.

Photo by New World, Everett CollectionWinona Ryder - Heathers
When Veronica realizes that her "friends" are merely pushy, petty princesses, she decides to join forces with Jason Dean to deliver a wake up call. However, things get out of hand as a Drano overdose and a fatal football shooting lead to an explosive pep rally.

Everett CollectionPam Grier - Coffy
Before Foxy Brown delivered beat downs, Pam Grier got her one-woman war on as Coffy, a nurse by day and vigilante by night, who combatted everyone from Mafiosos to crooked cops to drug smugglers in this groundbreaking blaxploitation flick.

Photo by Buena Vista/Kobal, WireImageRebecca De Mornay - The Hand That Rocks the Cradle
After suffering a miscarriage brought on by her husband's death, Rebecca De Mornay poses as a nanny and embarks on a journey of seduction and destruction. The model family she targets could have prevented a great amount of pain had they just invested in a Nanny Cam before allowing this seemingly sweet sociopath access to their happy home.

Photo by Tri-Star, Everett CollectionLinda Hamilton - Terminator 2: Judgment Day
Pumping iron while imprisoned paid off for Linda Hamilton's Sarah Connor, who emerged as a legitimate lethal lady by the time T2 hit theaters. Not only did she give Arnold a run for his money in the gun department, she also helped terminate the T-1000, delaying Judgment Day.

Photo by TriStar, Everett CollectionSharon Stone - Basic Instinct
When a brutal homicide mimics one within the pages of Catherine Trammel's latest tome, Michael Douglas crosses an ice pick-wielding Sharon Stone who unabashedly uncrosses her way into the history books as one of film's greatest femme fatales.

Photo by MCA, Everett CollectionT. Rex - Jurassic Park
With a penchant for SUVs, human flesh, and even fellow dinosaurs, the ferocious female T. Rex roared her way on to the big screen in 1993, proving that not all leading ladies prefer salad.

Photo by Warner Brothers, Everett CollectionMichelle Pfeiffer - Batman Returns
Skip Eartha Kitt; omit Lee Ann Meriwether; and permanently block Halle Berry. Michelle Pfeiffer's purrfect performance as the whip-cracking vinyl-clad villainess was the cat's meow.

Photo by Hollywood Pics/Kobal, WireImageDemi Moore - G.I. Jane
After sending the Women's Movement back to the dark ages with 1996's Striptease, Demi returned the following year in a truly feminist film in which she traded her sequins and stilettos for camo and combat boots. G.I. Jane was a force to be reckoned with, and Demi proved that her then-husband (Bruce Willis) wasn't the only action star under their roof.

Photo by Paramount, Everett CollectionGlenn Close - Fatal attraction
Long before Michael Douglas succumbed to Sharon Stone in Basic Instinct, he drove Glenn Close crazy when he told his on-screen stalker that their affair was simply a one night stand. Little did he know that Alex Forrest's borderline personality disorder would unleash an unforeseen fury on him, his marriage, and his daughter's pet rabbit.

Photo by UA/Kobal, WireImageLouise Fletcher - One Flew Over the Cuckoo's Nest
With electroshock therapy and neuroleptic drugs at her disposal, the unyielding authoritarian known as Nurse Ratched rules her mental institution with ease. When Jack Nicholson's Randle McMurphy shows up, he disrupts her master plan, but the troublemaker eventually pays the ultimate price when Ratched regains control and orders a lobotomy for her wild child.

Photo by Columbia, Everett CollectionZiyi Zhang - Crouching Tiger Hidden Dragon
When Ziyi's Jen learns to master the Green Destiny, a legendary sword, she went mano-a-mano against fellow high-kicking hottie Michelle Yeoh in this award-winning flick.

Photo by Warner Brothers, Everett CollectionJuliette Lewis - Natural Born Killers
In Oliver Stone's serial killer satire, Juliette Lewis massacres her way across the southwest, racking up 50+ victims, as a modern day Bonnie to Woody Harrelson's Clyde.

Photo by Warner Brothers, Everett CollectionTina Turner - Mad Max Beyond Thunderdome
A tyrannical Tina Turner dresses in post-apocalyptic garb to preside over bloody battles that take place in the deadly Thunderdome as "We Dont Need Another Hero" erupts. Need we say more?

Photo by Columbia/Kobal, WireImageMilla Jovovich - The Fifth Element
Before becoming a "Resident" action heroine, Milla Jovovich got her big break by busting butts as a bandage-wearing demi-god that held the key to mankind's survival.

Photo by United Artist, Everett CollectionSissy Spacek - Carrie
Before Kathy Bates bashed her way through a Stephen King adaptation in 1990's Misery, Sissy Spacek captivated audiences with her portrayal of Carrie, a social outcast who takes telekinetic revenge on her popular peers after being doused in pig's blood at the prom.

Photo by MGM/UA/Kobal, WireImageBrigitte Nielsen - Red Sonja
Flava Flav's former leading lady made a name for herself when she sported a mullet and assumed the role of the "She-Devil with a sword" alongside Arnold Schwarzenegger in this box office bomb that set the stage for her successor, Xena: Warrior Princess.

Photo by Paramount, Everett CollectionFaye Dunaway - Mommie Dearest
Don't get us wrong, this film is campy and cheesy, but there's no doubt you'll cringe at the sight of wire hangers for weeks to come once you've seen Faye Dunaway don mounds of monster makeup as she embodies the crazy that was Joan Crawford.

Everett CollectionFamke Janssen - Goldeneye
As Bond baddie Xenia Onatopp, the S&M-loving lust murderess uses her lethal legs to asphyxiate men by crushing their chests after luring them to their deaths with her sex appeal.

Everett CollectionNicole Kidman - To Die For
As ice cold Suzanne Stone attempts to climb the corporate ladder as a conniving yet talentless news anchor, she comes to realize that her hubby is holding her back. By copulating with and corrupting a local youth, she devises a plot to have her husband killed and her ratings rise.

Photo by Lucas Films/20th Century Fox/Kobal, WireImageCarrie Fisher - Return of the Jedi
Carrie Fisher's personal battles with addiction were way more thrilling than the battle sequences in Episode VI, but who can discount the woman who strangled notorious three ton gangster Jabba the Hutt to death while armed with nothing more than a metallic bikini and a rusty chain?

Photo by Miramax/Kobal, WireImageUma Thurman - Kill Bill Vol. 1
Uma slices and dices her way through an all-star ensemble that includes Vivica A. Fox as the venomous Vernita Green and a lethal Lucy Liu as O-Ren Ishii after waking from a coma and realizing that revenge is best served with a sharp sword.

Photo by 20th Century Fox, Everett CollectionRebecca Romijn - X2
As Mystique, the mutant that assists Magneto in his dirty deeds, Rebecca Romijn solidified the shapeshifter's supervillainess status by seducing Wolverine and punishing prison guards all while wearing carefully placed prosthetics.

Photo by Warner Brothers, Everett CollectionHilary Swank - Million Dollar Baby
Oscar winner Hilary Swank knocked everyone out with her tour-de-force performance as an amateur female boxer who dreams of making it big as a professional fighter in this fist-pumping, weep-inducing Best Picture winner.

Photo by Dark Horse/PolyGram/Kobal, WireImagePamela Anderson - Barb Wire
Based on the Dark Horse comic book of the same name, former Baywatch babe Pamela Anderson adorns little more than some strategically placed bubbles as a bodacious bounty hunter that exposes an illegal cover-up by the government ... in addition to her non-existent acting abilities.

Photo by Dreamland Productions/Kobal, WireImageDivine - Pink Flamingos
After being named "the filthiest person alive" by a local magazine, Babs Johnson engages in a crude competition with her rivals Connie and Raymond Marble. Along the way, she becomes an axe-murdering, hostage-taking, fecalfeliac with a heart of coal.

Photo by Columbia/Kobal, WireImageSarah Michelle Gellar - Cruel Intentions
Before girls were "Mean," they were Cruel. In this updated version of Dangerous Liaisons, SMG's Kathryn saunters around with a cocaine-loaded crucifix and spends her free time corrupting and destroying anyone that endangers her sacred reputation, even her own brother.

Photo by 20th Century Fox/Kobal, WireImageGene Tierney - Leave Her to Heaven
Gene Tierney laid the groundwork for all the disturbed dames of the past half century as she disowned, drowned, and even aborted her way through her husband's family tree in this classic film noir that proved beauty truly is a beast.

Photo by Universal, Everett CollectionJennifer Tilly - Bride of Chucky
Chucky's lady love, Tiffany, gets in on the action in the fourth installment of this humorous horror film. Voiced by Jennifer Tilly, this Barbie gone bad has a soft side for her main squeeze, yet isn't afraid to put him in his place ... or a knife in his back.

Photo by New Market, Everett CollectionCharlize Theron - Monster
Charlize scared many as prostitute turned serial killer Aileen Wuornos. By sporting an additional 30 lbs., prosthetic teeth, and the greasiest hairdo in history, the South African bombshell butchered her fellow nominees en route to Oscar gold.

Photo by Universal PicturesAngelina Jolie - Wanted
As Fox, an emotionally damaged elite assassin assigned to mentor James McAvoy's meek cubicle worker, Angelina Jolie proves why she's the big screen's ultimate slayer by butchering baddies left and right with the help of her awesome arsenal and deadly Dodge Viper SRT-10.

Everett CollectionMaleficent - Sleeping Beauty
Animation is rife with deranged villainesses, but none casts a darker shadow than Disney's Maleficent who uses her power to conjure up wicked prophecies, black thorn bushes, and even turns herself into a dragon to achieve the ultimate vengeance.

Everett CollectionJane Fonda - Barbarella
Though Jane Fonda has lasers, angels, and fabulous costumes to help her destruct the evil Duran Duran, she primarily relies upon her flirtatious forces to bend triumph in her favor as a space age siren.

Photo by Universal, Everett CollectionEstelle Getty - Stop! Or My Mom Will Shoot
When Golden Girl Estelle Getty pays a visit to her detective son (Sylvester Stallone) not only does she help him clean up the house, she also helps him clean up the streets thanks to her maternal instincts and her trusty MAC-10 submachine gun.