Rubin was plucked out of the University of Arizona for a modeling career by John Casablanca and won a talent competition that earned her the title Model of the Year before embarking on an international career. Eventually migrating to Hollywood, Rubin made guest appearances on "Miami Vice" and "The Twilight Zone" before winning a small role in the feature "A Nightmare on Elm Street 3: Dream Warriors" (1987). She had her first leading role as Cynthia, whose frightening visions become reality in "Bad Dreams" and then appeared in support of Keanu Reeves in "Permanent Record" and in the coming-of-age tale "Blueberry Hill" (all 1988). Rubin was the object of Ralph Macchio's desire in "Too Much Sun" and played a cameo as Edie Sedgwick in the Andy Warhol sequence of "The Doors" (both 1991). In "Bitter Harvest" (1993), she was a bank robber, while in "The Crush" (1993), she was Cary Elwes' girlfriend who runs afoul of Alicia Silverstone. Rubin was a soldier in search of the "Screamers" (1996) in the sci-fi thriller.
Rubin has worked less frequently on TV, usually in horror-thriller movies made for cable networks. In "Drop Dead Gorgeous" (USA, 1991), she was a young woman who is signed as a model only to have everyone she comes in contact with murdered by an admirer. In "Wasp Woman" (Showtime, 1995), Rubin was an aging model given wasp hormones as a youth serum with unexpected results.