Python(2001)

Scientist Anton Rudolph has spent years breeding and perfecting the ideal living weapon--a 60 foot long python that can swallow nearly anything in its path. Rudolph is transporting his new creation by air when their plane crashes near a small town and the gigantic snake escapes. Rudolph is forced to team up with Bart Parker, a military security expert, to hunt down the snake, but in the meantime, more than a few locals are pointing fingers at eccentric John Cooper, who has a fondness for snakes and a bad reputation with the local cops.