Six Degrees of Separation (1993)
U.S. Box Office: $6,311,061
Co-starring: Stockard Channing, Donald Sutherland, Ian McKellen, Mary Beth Hurt, Anthony Michael Hall and Heather Graham

Will Smith, in his first leading film role, plays a con artist posing as the son of Sidney Poitier, who worms his way into an upper-class New York family.

Independence Day (1996)
U.S. Box Office: $306,169,255
Co-starring: Bill Pullman, Jeff Goldblum, Mary McDonnell, Judd Hirsch and Vivica A. Fox

He hits box office pay dirt playing a cocky pilot who isn't afraid of clocking a killer alien square in the kisser. The first of his numerous July 4th blockbusters.

Men in Black (1997)
U.S. Box Office: $250,147,615
Co-starring: Tommy Lee Jones, Linda Fiorentino, Vincent D'Onofrio and Rip Torn

Smith battles aliens once again on the Fourth of July weekend. "ID4" put him on the map, but "MiB" sealed his standing as a box office draw.

Ali (2001)
U.S. Box Office: $58,183,966
Co-starring: Jamie Foxx, Jon Voight, Mario Van Peebles, Jeffrey Wright and Jada Pinkett-Smith

He garnered his first Oscar nomination for playing the legendary Muhammad Ali. He was nominated again in 2006 for The Pursuit of Happyness. Watch Trailer

I Am Legend (2007)
U.S. Box Office: $256,386,216
Co-starring: Alice Braga, Dash Mihok, Salli Richardson-Whitfield and Charlie Tahan

Smith carries this movie single-handedly. With the exception of a dog and CGI monsters, it's him and him alone in nearly every frame of the film. Watch Trailer